There are several other really cool ways to win but I found these at high ascension the best. Run winning combos can be Dead Branch + Corruption, Barricade + Entrench, Demon Form + defense to get it rolling (you don't need many offensive cards). In mid ascension I would try to take on more elites but towards the very end found that difficult. Other general advice is to remove or transform Strikes. Then I usually favored any Energy boss relics. Snecko Eye is great if you have several 2 or more cards. ![]() Obviously the boss relics make a huge difference as well. On mid ascensions I relied on either a lot of defense (Shrug It Offs, Ghostly Armor) and then sort of waited for the run to decide to go all in on defense (Barricade, Entrench) or go more offense with strength scaling (Spot Weakness, Inflame, Demon Form). Its hard to write a guide since each run is different but here is some general things I noticed. As you get to higher ascension different cards become more valuable.
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